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Both Jermaine Wright and defender Ady Williams will miss the trip to Huish Park and the game against Yeovil Town but Tottenham youngster Phil Ifil is available after being give clearance to play by his club.
Wright misses the game at the request of his parent club, Leeds United while 34-year-old Williams is cup tied having played in Coventry City's first-round victory over Rushden & Diamonds.
Paul Robinson and Don Hutchinson could both return to the side as a result while striker Carl Asaba is expected to start with Ben May an injury doubt after suffering back spasms during Millwall's 2-1 win at Hillsborough at the weekend.
Meanwhile Glovers boss Gary Johnson, who was linked with the vacant manager's position at The Den during the summer, has his own injury problems to worry about ahead of the tie.
On-loan Fulham central defender Liam Fontaine, Colin Miles and Argentine striker Pablo Bastianini all sustained injuries in the 1-1 draw against Brentford on Saturday.
Johnson is likely to welcome back Efe Sodje from a three match suspension to replace Fontaine while striker Matt Harrold could start up front. Fontaine's injury could also see Yeovil's new Uruguayan central defender Alejandro Melono make his debut as the West Country side look to continue their strong tradition of giant-killing Cup feats.