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Player-boss Wise has been battling to shake of the knee injury sustained against Tranmere Rovers in last Sunday's Quarter Final cup clash, while Darren Ward has a minor ligament strain.
The Lions travel to Ipswich with the opportunity to open a gap between themselves and the Tractor Boys at the top of the table. Millwall are currently sixth in the table, one place ahead of Ipswich by virtue of a superior goal difference.
Andy Roberts, Marvin Elliott and Mark McCammon all got a 45 minute run-out during the reserves 2-1 win against Crystal Palace on Wednesday and all three are likely to be involved at Portman Road, with Roberts poised to replace Ward in the heart of the Lions defence.