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Wise was substituted during Monday's home defeat to Rotherham United complaining that he'd lost the feeling in his legs and the Evening Standard reports that the club's medical team are baffled by the possible cause.
Inital thoughts suggested that the midfielder had picked up a back injury but this has been discounted after Wise was passed fit to play against The Millers.
Wise will be desperate to play at Molineux against his former manager, Glenn Hoddle, having lead The Lions to last year's FA Cup Final.